Research

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Research Behind Wellmune®

Unlike other yeast beta glucans, Wellmune® is the only ingredient supported by over a dozen published, peer-reviewed clinical studies. Research validates Wellmune’s unique ability to help support general immune health across all ages.

Wellmune – an immune trainer for everyday health

Wellmune® is the FIRST ingredient that has been clinically studied as an oral immune system trainer, providing a unique way of supporting immunity and everyday health.

Check out this video to learn more about trained innate immunity and how Wellmune can help train your immune system.

Unmatched science. 

Wellmune’s clinical research has demonstrated consistent results across a broad range of people, including:

Selected Clinical Studies

McFarlin, B.K. et al., Baker’s Yeast Beta Glucan Supplementation was Associated with an Improved Innate Immune mRNA Expression Response after Exercise. Methods, 2024 230:68-70. Baker’s yeast beta glucan supplementation was associated with an improved innate immune mRNA expression response after exercise – ScienceDirect

McFarlin, B.K., et al., Dry blood spot samples to monitor immune-associated mRNA expression in intervention studies: Impact of Baker’s yeast beta glucan. Methods, 2023. 219:39-47.
Dry blood spot samples to monitor immune-associated mRNA expression in intervention studies: Impact of Baker’s yeast beta glucan – PubMed (nih.gov)

Mah E, Kaden VN, Kelley KM and DJ Liska. (2018) Beverage Containing Dispersible Yeast B-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomized Controlled Trial. Journal of Dietary Supplements, DOI: 10.1080/19390211.2018.1495676.

McFarlin BK, Venable AS, Carpenter KC, Henning AL, Ogenstad S. (2017) Oral Supplementation with Baker’s Yeast Beta Glucan is Associated with Altered Monocytes, T Cells and Cytokines Following a Bout of Strenuous Exercise. Frontiers in Physiology 8:786.

Fuller R, Moore MV, Lewith G, Stuart BL, Ormiston RV, Fisk HL, Noakes PS, Calder PC. (2017) Yeast-Derived Beta 1,3/1,6 Glucan, Upper Respiratory Tract Infection and Innate Immunity in Older Adults. Nutrition 39-40:30-35.

Meng F. (2016) Baker’s Yeast Beta-Glucan Decreases Episodes of Common Child-hood Illness In 1 to 4 Year Old Children during Cold Season in China. Journal of Nutrition & Food Sciences 6:518.

Pontes MV, Ribeiro TCM, Ribeiro H, de Mattos AP, Almeida IR, Leal VM, Cabral GN, Stolz S, Zhuang W, Scalabrin DMF. (2016) Cow’s Milk-Based Beverage Consumption in 1- to 4-Year-Olds and Allergic Manifestations: an RCT. Nutrition Journal 15:19-28.

Li F, Jin X, Liu B, Zhuang W, Scalabrin D. (2014) Follow-up Formula Consumption in 3- to 4-Year-Olds and Respiratory Infections: An RCT. Pediatrics 133:e1533-40.

McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. (2013) Baker’s Yeast Beta Glucan Supplementation Increases Salivary IgA and Decreases Cold/Flu Symptomatic Days After Intense Exercise. Journal of Dietary Supplements 10:171-183.

Carpenter KC, Breslin WL, Davidson T, Adams A, McFarlin BK. (2013) Baker’s Yeast Beta-Glucan Supplementation Increases Monocytes and Cytokines Post-Exercise: Implications of Infection Risk? British Journal of Nutrition 109:478-486.

Talbott SM, Talbott JA, Talbott TL, Dingler E. (2013) “ß-Glucan Supplementation, Allergy Symptoms and Quality of Life in Self-Described Ragweed Allergy Sufferers“. Food Science & Nutrition 1:90-101

Fuller R, Butt H, Noakes PS, Kenyon J, Yam TS, Calder PC. (2012) Influence of Yeast-Derived 1,3/1,6 Glucopolysaccharide on Circulating Cytokines and Chemokines with Respect to Upper Respiratory Tract Infections. Nutrition 28:665-669.

Talbott SM, Talbott JA. (2012) Baker’s Yeast Beta-Glucan Supplement Reduces Upper Respiratory Symptoms and Improves Mood State in Stressed Women. Journal of the American College of Nutrition 31:295-300.

Talbott S, Talbott J. (2010) Beta 1,3/1,6 Glucan Decreases Upper Respiratory Tract Infection Symptoms and Improves Psychological Well-Being in Moderate to Highly-Stressed Subjects. Agro FOOD Industry Hi-Tech 21:21-24.

Talbott S, Talbott J. (2009) Effect of Beta 1,3/1,6 Glucan on Upper Respiratory Tract Infection Symptoms and Mood State in Marathon Athletes. Journal of Sports Science and Medicine 8:509-515.

Feldman S, Schwartz HI, Kalman DS, Mayers A, Kohrman HM, Clemens R, Krieger DR. (2009) Randomized Phase II Clinical Trials of Wellmune® for Immune Support During Cold and Flu Season. Journal of Applied Research 9:30-42.

Harger-Domitrovich SG, Domitrovich JW, Ruby BC. (2008) Effects of an Immunomodulating Supplement on Upper Respiratory Tract Infection Symptoms in Wildland Firefighters. Medicine & Science in Sports & Exercise 40:S353.

Preclinical Research

Horneck Johnston, C.J.H., et al., Recognition of yeast beta-glucan particles triggers immunometabolic signaling required for trained immunity. iScience, 2024. 27(3): p. 109030.
Recognition of yeast β-glucan particles triggers immunometabolic signaling required for trained immunity – PubMed (nih.gov)

Ganda Mall J-P, Casado-Bedmar M, Winberg ME, Brummer RJ, Schoultz I, Keita ÅV. (2017) A ß-glucan-based dietary fiber reduces mast cell-induced hyperpermeability in ileum from patients with Crohn’s disease and control subjects. Inflammatory Bowel Diseases 24:166-178.

Bose N, Wurst LR, Chan AS, Dudney CM, LeRoux ML, Danielson ME, Will PM, Nodland SE, Patchen ML, Dalle Lucca JJ, Lebeda FJ, Vasilakos JP. (2014) Differential Regulation of Oxidative Burst by Distinct ß-glucan-binding Receptors and Signaling Pathways in Human Peripheral Blood Mononuclear Cells. Glycobiology 24:379-391.

Goodridge HS, Reyes CN, Becker CA, Katsumoto TR, Ma J, Wolf AJ, Bose N, Chan AS, Magee AS, Danielson ME, Weiss A, Vasilakos JP, Underhill DM. (2011) Activation of the Innate Immune Receptor Dectin-1 upon Formation of a ‘Phagocytic Synapse’ . Nature 472:471-475.

Driscoll M, Hansen R, Ding C, Cramer DE, Yan J. (2009) Therapeutic Potential of Various Beta-Glucan Sources in Conjunction with Anti-tumor Monoclonal Antibody Therapy in Cancer Therapy. Cancer Biology & Therapy 8:218-25.

Babicek K, Cechova I, Simon RR, Harwood M, Cox DJ. (2007) Toxicological Assessment of a Particulate Yeast (1,3/1,6)-beta-D-glucan in Rats. Food and Chemical Toxicology 45:1719-1730.

Lavigne LM, Albina JE, Reichner JS. (2006) Beta-glucan is a Fungal Determinant for Adhesion-dependent Human Neutrophil Functions. Journal of Immunology 177:8667-8675.

Li B, Allendorf DJ, Hansen R, Marroquin J, Ding C, Cramer DE, Yan J. (2006) Yeast Beta-glucan Amplifies Phagocyte Killing of iC3b-opsonized Tumor Cells via Complement Receptor 3-Syk-Phosphatidylinositol 3-kinase Pathway. Journal of Immunology 177:1661-1669.

Cramer DE, Allendorf DJ, Baran JT, Hansen RD, Marroquin J, Li B, Ratajczak MZ, Yan J. (2006) Beta-glucan Enhances Complement-mediated Hematopoietic Recovery After Bone Marrow Injury. Blood 107:835-840.

Allendorf DJ, Yan J, Ross GD, Hansen RD, Baran JT, Subbarao K, Wang L, Haribabu B. (2005) C5a-mediated Leukotriene B4-amplified Neutrophil Chemotaxis is Essential in Tumor Immunotherapy Facilitated by Antitumor Monoclonal Antibody and Beta-Glucan. Journal of Immunology 174:7050-7056.

Yan J, Allendorf DJ, Brandley B. (2005) Yeast Whole Glucan Particle Beta-Glucan in Conjunction with Antitumor Monoclonal Antibodies to Treat Cancer. Expert Opinion on Biological Therapy 5:691-702.

Tsikitis VL, Albina JE, Reichner JS. (2004) Beta-Glucan Affects Leukocyte Navigation in a Complex Chemotactic Gradient. Surgery 136:384-389.

Hong F, Yan J, Baran JT, Allendorf DJ, Hansen RD, Ostroff G, Xing PX, Cheung NV, Ross GD. (2004) Mechanism by which Orally Administered Beta-1,3-Glucans Enhance the Tumoricidal Activity of Antitumor Monoclonal Antibodies in Murine Tumor Models. Journal of Immunology 173:797-806.