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Baker’s Yeast Beta-Glucan Supplement Reduces Upper Respiratory Symptoms and Improves Mood State in Stressed Women

Talbott SM, Talbott JA. (2012)

Journal of the American College of Nutrition 31:295-300


Objective: Several studies have shown a baker’s yeast beta-1,3/1,6-D-glucan, extracted from Saccharomyces cerevisiae, is effective in reducing the incidence of cold and flu symptoms. This study evaluated the effect of a specific beta-glucan supplement (Wellmune) on upper respiratory tract symptoms and psychological well-being in women with moderate levels of psychological stress.

Methods: Healthy women (38 + 12 years old) prescreened for moderate levels of psychological stress, self-administered a placebo (n = 38) or 250 mg of Wellmune (n = 39) daily for 12 weeks. We used the Profile of Mood States (POMS) psychological survey to assess changes in mental/physical energy levels (vigor) and overall well-being (global mood state). A quantitative health perception log was used to track upper respiratory symptoms.

Results: Subjects in the Wellmune group reported fewer upper respiratory symptoms compared to placebo (10% vs. 29%), better overall well-being (global mood state: 99 +  19 vs 108 + 23 p < 0.05), and superior mental/physical energy levels (vigor 19.9 + 4.7 vs 15.8 + 6.3, p < 0.05).

Conclusions: These data show that daily dietary supplementation with Wellmune reduces upper respiratory symptoms and improves mood state in stressed subjects, and thus it may be a useful approach for maintaining immune protection against daily stressors.


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